SNJ is a biotech company that specializes in developing and managing treatments for ischemic diseases caused by blood clots. Blood clot generation, also known as thrombosis, is the underlying pathology of major cardiovascular disorders such as ischemic heart disease (IHD), acute ischemic stroke (AIS), and venous thromboembolism (VTE). The current thrombolytic treatments available, tissue plasminogen activators (tPA), have significant bleeding risks and are only available to fewer than 10% of patients due to significant bleeding risks associated with these therapies. SNJ Pharma’s innovative drug SNJ101 aims to revolutionize the treatment of ischemic diseases by addressing the bleeding complications associated with current thrombolytic therapies, providing a therapeutic option for over 200 million patients.
It is estimated that over 126.5 million individuals suffer from Ischemic Heart Disease and 104.2 million people experience Acute Ischemic Stroke annually without effective treatment, resulting in one in four deaths globally. The target market for SNJ101 is projected to be valued at US$ 25 Billion.
SNJ101 is a recombinant HtrA1 (High-Temperature Requirement A1) protein that exhibits specific thrombolytic activity through a plasmin-independent pathway (Circulation Research 2021;128:386, PMID: 33292062).
SNJ101 has been demonstrated to be safer than tPA in animal studies, as it does not generate plasmin, does not disrupt normal wound healing, does not cause abnormal bleeding or hemorrhage, and has superior efficacy compared to current thrombolytic therapies.
SNJ101 is eligible for the FDA’s Expedited Drug Approval programs due to its advantages over tPA, including improved effectiveness on serious outcomes and lesser side effects. This designation will expedite the regulatory process for SNJ101.
The intellectual property of SNJ101 is protected by 2 fully issued patents and 9 pending patents in the US and internationally.
Title: Identification and Characterization of Plasmin-Independent Thrombolytic Enzymes
SNJ was selected for the NINDS Small Business Program which provides support to small businesses to develop products addressing unmet clinical and research needs.